COVID-19: Anatomy, Physiology, Pharmacology and Treatment | Association of American Physicians and Surgeons | Jun 5, 2021 (Video)

 
Content Source/Owner:
 
Association of American Physicians and Surgeons
 
 
 
1 hr 40 min
Summary:

 

June 3, 2021 webinar led by Harpal Mangat, MD
 
Meeting Notes and Time marker (credit: Mark Steudlein https://www.youtube.com/channel/UCc4Vb0UInP62sQt_RqkqMNg/)
 
1. Intro – 0:00 
2. Dr Harpal Mangat – 4:28 
 
a. ACE Fundamentals – 8:00 
    i. Avoid Ibuprofen  
b. Bronchial Evidence –11:28 
 
c. JAK STAT Pathway – 12:56 
    i. Medications, preventing cytokine storm  
    1. Famotidine 2. Barictinab 3. Apoquel (dogs)   
 
d. Coronaviruses – 14:14   
e. Covid Habitat 15:36 
f. Covid-19 – 15:57 
   i. Not a natural virus
   
g. Treatment Key Slide – 18:17 
    i. Early treatment is key to mortality  
 
h. Objective Phase 0 Treatment – 24:00 
     i. Prevent Covid getting to lungs  
     1. Nasal rinses 2. Bevespi/Breztri 3. Ipratropium 4. Ciclesonide, Budnesonide  
 
i. Phase Zero Treatment – 26:10 
   i. Same as above  
   1. Sotrovimab   
 
j. Intracellular Covid Life Cycle – 28:03 
   i. Goal 1 – Prevent ACE2 activation  
   1. Regeneron-cov, Bamlanivimab+Etasvinmab, Sotrovimb  
 
   ii. Goal 2 – Shut down Bradykinin storm 
   1. Bendryl (diphenylhydramine)  
 
k. Objective Phase 1 Treatment – 32:00 
    i. 2-6 days to get viral load to zero  
 
l. Criteria for Antibody Usage – 33:08 
 
m. Phase 2 Treatment – 33:50 
     i. Goal 1 – Prevent RNA Replication  
     1. hydroxychloroquine 2. Remdesevir 3. [avoid] Favipiravir  
 
n. Phase 3 Treatment – 40:27 
    i. Goal 1 – Inhibit Cytokine signal 
    1. Pepsid (Famotidine, Baricitinab)  
 
o. Use Case 1 and Treatment – 41:54   
p. Use Case 2 and Treatment – 46:40 
 
q. Phase 4 Treatment – 54:00 
    i. Goal 1 – Reduce Cytokine Storm  
    1. Toclizumab 2. Eliquis  
 
r. Recap of early treatment – 55:25 
   i. Results ii. Contacts  
 
s. Additional Use Cases – 57:29 
t. Multidrug treatment study – 1:16:20   
 
u. Conclusions – 1:17:45   
v. Questions – 1:19:00

  

 
 
 

 
 
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